The SportsLine Projection Model, which enters Week 1 on a 53-37 run on top-rated picks dating back to 2024, has revealed its Week 1 NFL score predictions
A new season brings about new expectations. Among the teams expected to make a Super Bowl run includes the Los Angeles Rams, who seriously upgraded their defense over the offseason, bringing in Myles Garrett and expecting Aaron Donald to unretire. Garrett spent the past nine seasons with the Cleveland Browns and was named the 2025 NFL Defensive Player of the Year honors after breaking the single-season sack record with 23. Donald spent his entire 10-year career with the Rams before retiring in March 2024. He had 111 career sacks, including 20.5 in 2018.
The Rams are 3.5-point favorites over the 49ers at Melbourne, Australia, on Sept. 10 in the latest Week 1 NFL odds. Other notable NFL spreads on the Week 1 NFL schedule include Patriots vs. Seahawks (-3.5, 44.5), Bills vs. Texans (+1.5, 44.5), and Cowboys vs. Giants (+2.5, 48.5). SportsLine’s advanced NFL model has revealed its exact NFL score predictions for every game of Week 1, which could mean a HUGE payday of well over 100-1 if any of them hits. Before you lock in any Week 1 NFL picks, make sure you see what SportsLine’s advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2026 NFL season on a 53-37 roll on top-rated NFL picks since 2024.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following has seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 1 of the 2026 NFL season, and the results are in.
We can tell you SportsLine’s model likes the Philadelphia Eagles (-4.5, 40.5) to beat the Washington Commanders, 27-18, at home. The Eagles have dominated this series recently, winning seven of the last 10 meetings against the Commanders. Washington has dropped eight of their last 10 games overall, while Philadelphia has won three of its last five games. In addition, the Commanders are 5-4-1 against the spread in their last 10 games against Philadelphia. The model projects Jalen Hurts of the Eagles will throw for 213 yards and 1.79 touchdowns, while Washington’s defense racks up 2.64 sacks on average.
In addition, the model is calling for one specific underdog to pull off a SHOCKING upset! Nailing these results is key to making profitable Week 1 NFL picks. You ABSOLUTELY NEED to see who to pick before locking in any Week 1 NFL score predictions!
What are the projected scores for every Week 1 NFL game? And which underdog shocks the NFL? … Join SportsLine now to get NFL Week 1 score predictions, all from the model on a dominant 53-37 roll!
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