A pair of NFC West contenders open their regular seasons when the San Francisco 49ers battle the Los Angeles Rams in a 2026 Week 1 matchup in Melbourne, Australia. Both teams tied for second in the division with 12-5 records last year. The Rams fell short to the eventual champion Seattle Seahawks 31-27 in the NFC Championship Game. The 49ers also were eliminated by the Seahawks, losing 41-6 in a divisional round matchup.
Kickoff is at 8:35 p.m. ET from Melbourne Cricket Ground. The latest 49ers vs. Rams odds have Los Angeles as 3.5-point favorites, while the over/under for total points scored is 48.5 via SportsLine consensus.
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Now, the model has locked in another confident pick for 49ers vs. Rams on Thursday, Sept. 10.
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